MIPR NUMBER 94 MM 4559 TITLE : Breast Tissue Dosimetry of PhIP
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A study on dosimetry accuracy of Strut-Adjust Volume Implant (SAVI) brachytherapy
Introduction: Accelerated Partial Breast Irradiation (APBI) is an effective treatment for breast carcinomas because of its limited number of fractions. Strut-adjusted volume implant (SAVI) is a HDR brachytherapy applicator to deliver the prescription dose with good PTV coverage and acceptable dose to skin, chest wall and organ at risks. Acceptable clinical outcomes depend on a...
متن کاملAward Number : W 81 XWH - 06 - 1 - 0138 TITLE : Interactions between Dietary Factors and Inflammation in Prostate
Exposure of Fisher344 rats to 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a heterocyclic amine in cooked meat, causes cancer in the rat ventral prostate, while sparing the dorsolateral and anterior lobes. Uncovering the molecular mechanisms of the lobe specificity of PhIP-induced rat prostate cancer may provide clues to the pathogenesis of human prostate cancer, which is also lobe s...
متن کاملThe cooked meat-derived mammary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) elicits estrogenic-like microRNA responses in breast cancer cells.
The cooking of meat results in the generation of heterocyclic amines (HCA), the most abundant of which is 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Data from epidemiological, mechanistic, and animal studies indicate that PhIP could be causally linked to breast cancer incidence. Besides the established DNA damaging and mutagenic activities of PhIP, the chemical is reported to have ...
متن کاملMonte Carlo investigation on precise dosimetry of HDR breast brachytherapy with Accuboost
Introduction: Accuboost is a HDR brachytherapy system in early stages breast cancer treatment. This device provides a completely noninvasive procedure with parallel-opposed radiation from two immobilizing peripheral applicators that caused it a preferred option of modalities to choose. In most commercial treatment planning systems, tissues are considered as a simple water phan...
متن کاملShort Communication 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine Induces a Higher Number of Aberrant Crypt Foci in Fischer 344 (Rapid) Than in Wistar Kyoto (Slow) Acetylator Inbred Rats
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is the most abundant heterocyclic amine carcinogen in the human diet and is a colon carcinogen in the rat. NAcetyltransferase-2 (NAT2) catalyzes the conversion of PhIP and other heterocyclic amines to a DNA-reactive form. NAT2 has a polymorphic distribution in humans and other mammals, including rats. The rapid NAT2 genotype has been shown ...
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تاریخ انتشار 1999